Autophagy in malignant transformation and cancer progression
Identifieur interne : 000F78 ( Main/Exploration ); précédent : 000F77; suivant : 000F79Autophagy in malignant transformation and cancer progression
Auteurs : Lorenzo Galluzzi [France, Italie] ; Federico Pietrocola [France] ; José Manuel Bravo-San Pedro [France] ; Ravi K. Amaravadi [États-Unis] ; Eric H. Baehrecke [États-Unis] ; Francesco Cecconi [Danemark, Italie] ; Patrice Codogno [France] ; Jayanta Debnath [États-Unis] ; David A. Gewirtz [États-Unis] ; Vassiliki Karantza [États-Unis] ; Alec Kimmelman [États-Unis] ; Sharad Kumar [Australie] ; Beth Levine [États-Unis] ; Maria Chiara Maiuri [France] ; Seamus J. Martin [Irlande (pays)] ; Josef Penninger [Autriche] ; Mauro Piacentini [Italie] ; David C. Rubinsztein [Royaume-Uni] ; Hans-Uwe Simon [Suisse] ; Anne Simonsen [Norvège] ; Andrew M. Thorburn [États-Unis] ; Guillermo Velasco [Espagne] ; Kevin M. Ryan [Royaume-Uni] ; Guido Kroemer [France]Source :
- The EMBO Journal [ 0261-4189 ] ; 2015-04-01.
Abstract
Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.
Autophagy has been described to have tumor‐suppressive as well as tumor‐promoting functions. This review discusses how stage and context alters the role for autophagy in cancer, and argues for further research prior to targeting autophagy in cancer therapy.
Url:
DOI: 10.15252/embj.201490784
Affiliations:
- Australie, Autriche, Danemark, Espagne, France, Irlande (pays), Italie, Norvège, Royaume-Uni, Suisse, États-Unis
- Angleterre, Angleterre de l'Est, Californie, Canton de Berne, Communauté de Madrid, Hovedstaden, Latium, Massachusetts, Pennsylvanie, Texas, Vienne (Autriche), Île-de-France, Østlandet
- Berne, Boston, Cambridge, Copenhague, Dallas, Madrid, Oslo, Paris, Philadelphie, Rome, San Francisco, Vienne (Autriche)
- Université Paris-Descartes, Université de Berne, Université de Cambridge
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000318
- to stream Istex, to step Curation: 000318
- to stream Istex, to step Checkpoint: 000123
- to stream Main, to step Merge: 000F79
- to stream Main, to step Curation: 000F78
Le document en format XML
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Amaravadi</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Abramson Cancer Center, University of Pennsylvania, PA, Philadelphia</wicri:regionArea><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Baehrecke, Eric H" sort="Baehrecke, Eric H" uniqKey="Baehrecke E" first="Eric H" last="Baehrecke">Eric H. Baehrecke</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, MA, Worcester</wicri:regionArea><wicri:noRegion>Worcester</wicri:noRegion></affiliation></author><author><name sortKey="Cecconi, Francesco" sort="Cecconi, Francesco" uniqKey="Cecconi F" first="Francesco" last="Cecconi">Francesco Cecconi</name><affiliation wicri:level="3"><country xml:lang="fr">Danemark</country><wicri:regionArea>Cell Stress and Survival Unit, Danish Cancer Society Research Center, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>IRCCS Fondazione Santa Lucia and Department of Biology, University of Rome Tor Vergata, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Institut Necker Enfants‐Malades (INEM), Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1151, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CNRS, UMR8253, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Debnath, Jayanta" sort="Debnath, Jayanta" uniqKey="Debnath J" first="Jayanta" last="Debnath">Jayanta Debnath</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, CA, San Francisco</wicri:regionArea><placeName><settlement type="city">San Francisco</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Gewirtz, David A" sort="Gewirtz, David A" uniqKey="Gewirtz D" first="David A" last="Gewirtz">David A. Gewirtz</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, Toxicology and Medicine, Virginia Commonwealth University, VA, RichmondVirginia</wicri:regionArea><wicri:noRegion>RichmondVirginia</wicri:noRegion></affiliation></author><author><name sortKey="Karantza, Vassiliki" sort="Karantza, Vassiliki" uniqKey="Karantza V" first="Vassiliki" last="Karantza">Vassiliki Karantza</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Merck Research Laboratories, NJ, Rahway</wicri:regionArea><wicri:noRegion>Rahway</wicri:noRegion></affiliation></author><author><name sortKey="Kimmelman, Alec" sort="Kimmelman, Alec" uniqKey="Kimmelman A" first="Alec" last="Kimmelman">Alec Kimmelman</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Genomic Stability and DNA Repair, Department of Radiation Oncology, Dana‐Farber Cancer Institute, MA, Boston</wicri:regionArea><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kumar, Sharad" sort="Kumar, Sharad" uniqKey="Kumar S" first="Sharad" last="Kumar">Sharad Kumar</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Cancer Biology, University of South Australia, SA, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Levine, Beth" sort="Levine, Beth" uniqKey="Levine B" first="Beth" last="Levine">Beth Levine</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Autophagy Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, TX, Dallas</wicri:regionArea><placeName><settlement type="city">Dallas</settlement><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Maiuri, Maria Chiara" sort="Maiuri, Maria Chiara" uniqKey="Maiuri M" first="Maria Chiara" last="Maiuri">Maria Chiara Maiuri</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1138, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Seamus J" sort="Martin, Seamus J" uniqKey="Martin S" first="Seamus J" last="Martin">Seamus J. Martin</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Genetics, Trinity College, The Smurfit Institute, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Penninger, Josef" sort="Penninger, Josef" uniqKey="Penninger J" first="Josef" last="Penninger">Josef Penninger</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Piacentini, Mauro" sort="Piacentini, Mauro" uniqKey="Piacentini M" first="Mauro" last="Piacentini">Mauro Piacentini</name><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biology, University of Rome Tor Vergata, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Italie</country><wicri:regionArea>National Institute for Infectious Diseases IRCCS ‘Lazzaro Spallanzani’, Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Simon, Hans We" sort="Simon, Hans We" uniqKey="Simon H" first="Hans-Uwe" last="Simon">Hans-Uwe Simon</name><affiliation wicri:level="4"><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmacology, University of Bern, Bern</wicri:regionArea><placeName><settlement type="city">Berne</settlement><region type="région" nuts="3">Canton de Berne</region></placeName><orgName type="university">Université de Berne</orgName></affiliation></author><author><name sortKey="Simonsen, Anne" sort="Simonsen, Anne" uniqKey="Simonsen A" first="Anne" last="Simonsen">Anne Simonsen</name><affiliation wicri:level="3"><country xml:lang="fr">Norvège</country><wicri:regionArea>Institute of Basic Medical Sciences, University of Oslo, Oslo</wicri:regionArea><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Thorburn, Andrew M" sort="Thorburn, Andrew M" uniqKey="Thorburn A" first="Andrew M" last="Thorburn">Andrew M. Thorburn</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology, University of Colorado School of Medicine, CO, Aurora</wicri:regionArea><wicri:noRegion>Aurora</wicri:noRegion></affiliation></author><author><name sortKey="Velasco, Guillermo" sort="Velasco, Guillermo" uniqKey="Velasco G" first="Guillermo" last="Velasco">Guillermo Velasco</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University of Madrid, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Instituto de Investigaciones Sanitarias San Carlos (IdISSC), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Ryan, Kevin M" sort="Ryan, Kevin M" uniqKey="Ryan K" first="Kevin M" last="Ryan">Kevin M. Ryan</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research UK Beatson Institute, Glasgow</wicri:regionArea><wicri:noRegion>Glasgow</wicri:noRegion></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Equipe 11 labellisée pas la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1138, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université Paris Descartes, Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Paris-Descartes</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Pôle de Biologie, Hôpital Européen Georges Pompidou, AP‐HP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The EMBO Journal</title><title level="j" type="alt">THE EMBO JOURNAL</title><idno type="ISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><imprint><biblScope unit="vol">34</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="856">856</biblScope><biblScope unit="page" to="880">880</biblScope><biblScope unit="page-count">25</biblScope><date type="published" when="2015-04-01">2015-04-01</date></imprint><idno type="ISSN">0261-4189</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0261-4189</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Autophagy plays a key role in the maintenance of cellular homeostasis. In healthy cells, such a homeostatic activity constitutes a robust barrier against malignant transformation. Accordingly, many oncoproteins inhibit, and several oncosuppressor proteins promote, autophagy. Moreover, autophagy is required for optimal anticancer immunosurveillance. In neoplastic cells, however, autophagic responses constitute a means to cope with intracellular and environmental stress, thus favoring tumor progression. This implies that at least in some cases, oncogenesis proceeds along with a temporary inhibition of autophagy or a gain of molecular functions that antagonize its oncosuppressive activity. Here, we discuss the differential impact of autophagy on distinct phases of tumorigenesis and the implications of this concept for the use of autophagy modulators in cancer therapy.</div><div type="abstract" xml:lang="en">Autophagy has been described to have tumor‐suppressive as well as tumor‐promoting functions. This review discusses how stage and context alters the role for autophagy in cancer, and argues for further research prior to targeting autophagy in cancer therapy.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Autriche</li><li>Danemark</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Californie</li><li>Canton de Berne</li><li>Communauté de Madrid</li><li>Hovedstaden</li><li>Latium</li><li>Massachusetts</li><li>Pennsylvanie</li><li>Texas</li><li>Vienne (Autriche)</li><li>Île-de-France</li><li>Østlandet</li></region><settlement><li>Berne</li><li>Boston</li><li>Cambridge</li><li>Copenhague</li><li>Dallas</li><li>Madrid</li><li>Oslo</li><li>Paris</li><li>Philadelphie</li><li>Rome</li><li>San Francisco</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université Paris-Descartes</li><li>Université de Berne</li><li>Université de Cambridge</li></orgName></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name></region><name sortKey="Bravo An Pedro, Jose Manuel" sort="Bravo An Pedro, Jose Manuel" uniqKey="Bravo An Pedro J" first="José Manuel" last="Bravo-San Pedro">José Manuel Bravo-San Pedro</name><name sortKey="Bravo An Pedro, Jose Manuel" sort="Bravo An Pedro, Jose Manuel" uniqKey="Bravo An Pedro J" first="José Manuel" last="Bravo-San Pedro">José Manuel Bravo-San Pedro</name><name sortKey="Bravo An Pedro, Jose Manuel" sort="Bravo An Pedro, Jose Manuel" uniqKey="Bravo An Pedro J" first="José Manuel" last="Bravo-San Pedro">José Manuel Bravo-San Pedro</name><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name><name sortKey="Codogno, Patrice" sort="Codogno, Patrice" uniqKey="Codogno P" first="Patrice" last="Codogno">Patrice Codogno</name><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Maiuri, Maria Chiara" sort="Maiuri, Maria Chiara" uniqKey="Maiuri M" first="Maria Chiara" last="Maiuri">Maria Chiara Maiuri</name><name sortKey="Maiuri, Maria Chiara" sort="Maiuri, Maria Chiara" uniqKey="Maiuri M" first="Maria Chiara" last="Maiuri">Maria Chiara Maiuri</name><name sortKey="Maiuri, Maria Chiara" sort="Maiuri, Maria Chiara" uniqKey="Maiuri M" first="Maria Chiara" last="Maiuri">Maria Chiara Maiuri</name><name sortKey="Pietrocola, Federico" sort="Pietrocola, Federico" uniqKey="Pietrocola F" first="Federico" last="Pietrocola">Federico Pietrocola</name><name sortKey="Pietrocola, Federico" sort="Pietrocola, Federico" uniqKey="Pietrocola F" first="Federico" last="Pietrocola">Federico Pietrocola</name><name sortKey="Pietrocola, Federico" sort="Pietrocola, Federico" uniqKey="Pietrocola F" first="Federico" last="Pietrocola">Federico Pietrocola</name></country><country name="Italie"><noRegion><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name></noRegion><name sortKey="Cecconi, Francesco" sort="Cecconi, Francesco" uniqKey="Cecconi F" first="Francesco" last="Cecconi">Francesco Cecconi</name><name sortKey="Piacentini, Mauro" sort="Piacentini, Mauro" uniqKey="Piacentini M" first="Mauro" last="Piacentini">Mauro Piacentini</name><name sortKey="Piacentini, Mauro" sort="Piacentini, Mauro" uniqKey="Piacentini M" first="Mauro" last="Piacentini">Mauro Piacentini</name></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Amaravadi, Ravi K" sort="Amaravadi, Ravi K" uniqKey="Amaravadi R" first="Ravi K" last="Amaravadi">Ravi K. Amaravadi</name></region><name sortKey="Baehrecke, Eric H" sort="Baehrecke, Eric H" uniqKey="Baehrecke E" first="Eric H" last="Baehrecke">Eric H. Baehrecke</name><name sortKey="Debnath, Jayanta" sort="Debnath, Jayanta" uniqKey="Debnath J" first="Jayanta" last="Debnath">Jayanta Debnath</name><name sortKey="Gewirtz, David A" sort="Gewirtz, David A" uniqKey="Gewirtz D" first="David A" last="Gewirtz">David A. Gewirtz</name><name sortKey="Karantza, Vassiliki" sort="Karantza, Vassiliki" uniqKey="Karantza V" first="Vassiliki" last="Karantza">Vassiliki Karantza</name><name sortKey="Kimmelman, Alec" sort="Kimmelman, Alec" uniqKey="Kimmelman A" first="Alec" last="Kimmelman">Alec Kimmelman</name><name sortKey="Levine, Beth" sort="Levine, Beth" uniqKey="Levine B" first="Beth" last="Levine">Beth Levine</name><name sortKey="Levine, Beth" sort="Levine, Beth" uniqKey="Levine B" first="Beth" last="Levine">Beth Levine</name><name sortKey="Levine, Beth" sort="Levine, Beth" uniqKey="Levine B" first="Beth" last="Levine">Beth Levine</name><name sortKey="Thorburn, Andrew M" sort="Thorburn, Andrew M" uniqKey="Thorburn A" first="Andrew M" last="Thorburn">Andrew M. Thorburn</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Cecconi, Francesco" sort="Cecconi, Francesco" uniqKey="Cecconi F" first="Francesco" last="Cecconi">Francesco Cecconi</name></region></country><country name="Australie"><noRegion><name sortKey="Kumar, Sharad" sort="Kumar, Sharad" uniqKey="Kumar S" first="Sharad" last="Kumar">Sharad Kumar</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="Martin, Seamus J" sort="Martin, Seamus J" uniqKey="Martin S" first="Seamus J" last="Martin">Seamus J. Martin</name></noRegion></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Penninger, Josef" sort="Penninger, Josef" uniqKey="Penninger J" first="Josef" last="Penninger">Josef Penninger</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Rubinsztein, David C" sort="Rubinsztein, David C" uniqKey="Rubinsztein D" first="David C" last="Rubinsztein">David C. Rubinsztein</name></region><name sortKey="Ryan, Kevin M" sort="Ryan, Kevin M" uniqKey="Ryan K" first="Kevin M" last="Ryan">Kevin M. Ryan</name></country><country name="Suisse"><region name="Canton de Berne"><name sortKey="Simon, Hans We" sort="Simon, Hans We" uniqKey="Simon H" first="Hans-Uwe" last="Simon">Hans-Uwe Simon</name></region></country><country name="Norvège"><region name="Østlandet"><name sortKey="Simonsen, Anne" sort="Simonsen, Anne" uniqKey="Simonsen A" first="Anne" last="Simonsen">Anne Simonsen</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Velasco, Guillermo" sort="Velasco, Guillermo" uniqKey="Velasco G" first="Guillermo" last="Velasco">Guillermo Velasco</name></region><name sortKey="Velasco, Guillermo" sort="Velasco, Guillermo" uniqKey="Velasco G" first="Guillermo" last="Velasco">Guillermo Velasco</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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